Acetylcholine enhances excitability by lowering the threshold 4 of spike generation in olfactory receptor cells
نویسندگان
چکیده
JN-01077-2012R2 2 3 Acetylcholine enhances excitability by lowering the threshold 4 of spike generation in olfactory receptor cells 5 6 Mahito Ohkuma, Fusao Kawai*, and Ei-ichi Miyachi 7 Department of Physiology, Fujita Health University, School of Medicine, 8 Toyoake, Aichi, 470-1192, Japan 9 10 Running Head: ACETYLCHOLINE ENHANCES EXCITABILITY IN 11 OLFACTORY CELLS 12 13 14 * Address for Correspondence: 15 Dr. Fusao KAWAI 16 Department of Physiology, Fujita Health University, School of Medicine, 17 1-98 Dengakugakubo, Kutsukake-cho, Toyoake, Aichi, 470-1192, Japan 18 Tel: +81-562-93-2466 (Office) Fax: +81-562-93-2649 (Univ. Library) 19 E-mail: [email protected] 20
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Acetylcholine enhances excitability by lowering the threshold of spike generation in olfactory receptor cells.
Olfactory perception is influenced by behavioral states, presumably via efferent regulation. Using the whole cell version of patch-clamp recording technique, we discovered that acetylcholine, which is released from efferent fibers in the olfactory mucosa, can directly affect the signal encoding in newt olfactory receptor cells (ORCs). Under current-clamp conditions, application of carbachol, an...
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